Relaxant Action of Diclofenac Sodium on Mouse Airway Smooth Muscle
Identifieur interne : 000473 ( Main/Exploration ); précédent : 000472; suivant : 000474Relaxant Action of Diclofenac Sodium on Mouse Airway Smooth Muscle
Auteurs : Chunfa Chen [République populaire de Chine] ; Yongle Yang [République populaire de Chine] ; Meng-Fei Yu [République populaire de Chine] ; Shunbo Shi [République populaire de Chine] ; Shuhui Han [République populaire de Chine] ; Qing-Hua Liu [République populaire de Chine] ; Congli Cai [République populaire de Chine] ; Jinhua Shen [République populaire de Chine]Source :
- Frontiers in Pharmacology [ 1663-9812 ] ; 2019.
Abstract
Diclofenac sodium (DCF) is a nonsteroidal anti-inflammatory drug (NSAID) and is widely used as an analgesic and anti-inflammatory agent. Herein, we found that DCF could relax high K+ (80 mM K+)-/ACh-precontracted tracheal rings (TRs) in mice. This study aimed to elucidate the underlying mechanisms of DCF-induced relaxations. The effects of DCF on airway smooth muscle (ASM) cells were explored using multiple biophysiological techniques, such as isometric tension measurement and patch-clamping experiments. Both high K+- and ACh-evoked contraction of TRs in mice were relaxed by DCF in a dose-dependent manner. The results of isometric tension and patch-clamping experiments demonstrated that DCF-induced relaxation in ASM cells was mediated by cytosolic free Ca2+, which was decreased via inhibition of voltage-dependent L-type Ca2+ channels (VDLCCs), nonselective cation channels (NSCCs), and Na+/Ca2+ exchange. Meanwhile, DCF also enhanced large conductance Ca2+ activated K+ (BK) channels, which led to the relaxation of ASMs. Our data demonstrated that DCF relaxed ASMs by decreasing the intracellular Ca2+ concentration via inhibition of Ca2+ influx and Na+/Ca2+ exchange. Meanwhile, the enhanced BK channels also played a role in DCF-induced relaxation in ASMs. These results suggest that DCF is a potential candidate for antibronchospasmic drugs used in treating respiratory diseases such as asthma and chronic obstructive pulmonary disease.
Url:
DOI: 10.3389/fphar.2019.00608
PubMed: 31275141
PubMed Central: 6591797
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream Pmc, to step Corpus: 000568
- to stream Pmc, to step Curation: 000568
- to stream Pmc, to step Checkpoint: 000429
- to stream Ncbi, to step Merge: 000770
- to stream Ncbi, to step Curation: 000770
- to stream Ncbi, to step Checkpoint: 000770
- to stream Main, to step Merge: 000473
- to stream Main, to step Curation: 000473
Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Relaxant Action of Diclofenac Sodium on Mouse Airway Smooth Muscle</title><author><name sortKey="Chen, Chunfa" sort="Chen, Chunfa" uniqKey="Chen C" first="Chunfa" last="Chen">Chunfa Chen</name><affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Institute for Medical Biology, Hubei Provincial Key Laboratory for Protection and Application of Special Plant Germplasm in Wuling Area of China, College of Life Sciences, South-Central University for Nationalities</institution>,<addr-line>Wuhan</addr-line>,<country>China</country></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Yang, Yongle" sort="Yang, Yongle" uniqKey="Yang Y" first="Yongle" last="Yang">Yongle Yang</name><affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Institute for Medical Biology, Hubei Provincial Key Laboratory for Protection and Application of Special Plant Germplasm in Wuling Area of China, College of Life Sciences, South-Central University for Nationalities</institution>,<addr-line>Wuhan</addr-line>,<country>China</country></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Yu, Meng Fei" sort="Yu, Meng Fei" uniqKey="Yu M" first="Meng-Fei" last="Yu">Meng-Fei Yu</name><affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Institute for Medical Biology, Hubei Provincial Key Laboratory for Protection and Application of Special Plant Germplasm in Wuling Area of China, College of Life Sciences, South-Central University for Nationalities</institution>,<addr-line>Wuhan</addr-line>,<country>China</country></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Shi, Shunbo" sort="Shi, Shunbo" uniqKey="Shi S" first="Shunbo" last="Shi">Shunbo Shi</name><affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Institute for Medical Biology, Hubei Provincial Key Laboratory for Protection and Application of Special Plant Germplasm in Wuling Area of China, College of Life Sciences, South-Central University for Nationalities</institution>,<addr-line>Wuhan</addr-line>,<country>China</country></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Han, Shuhui" sort="Han, Shuhui" uniqKey="Han S" first="Shuhui" last="Han">Shuhui Han</name><affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Institute for Medical Biology, Hubei Provincial Key Laboratory for Protection and Application of Special Plant Germplasm in Wuling Area of China, College of Life Sciences, South-Central University for Nationalities</institution>,<addr-line>Wuhan</addr-line>,<country>China</country></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Liu, Qing Hua" sort="Liu, Qing Hua" uniqKey="Liu Q" first="Qing-Hua" last="Liu">Qing-Hua Liu</name><affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Institute for Medical Biology, Hubei Provincial Key Laboratory for Protection and Application of Special Plant Germplasm in Wuling Area of China, College of Life Sciences, South-Central University for Nationalities</institution>,<addr-line>Wuhan</addr-line>,<country>China</country></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Cai, Congli" sort="Cai, Congli" uniqKey="Cai C" first="Congli" last="Cai">Congli Cai</name><affiliation wicri:level="1"><nlm:aff id="aff2"><institution>Department of Molecular Biology, Wuhan Youzhiyou Biopharmaceutical Co. Ltd.</institution>,<addr-line>Wuhan</addr-line>,<country>China</country></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Shen, Jinhua" sort="Shen, Jinhua" uniqKey="Shen J" first="Jinhua" last="Shen">Jinhua Shen</name><affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Institute for Medical Biology, Hubei Provincial Key Laboratory for Protection and Application of Special Plant Germplasm in Wuling Area of China, College of Life Sciences, South-Central University for Nationalities</institution>,<addr-line>Wuhan</addr-line>,<country>China</country></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">31275141</idno><idno type="pmc">6591797</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6591797</idno><idno type="RBID">PMC:6591797</idno><idno type="doi">10.3389/fphar.2019.00608</idno><date when="2019">2019</date><idno type="wicri:Area/Pmc/Corpus">000568</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000568</idno><idno type="wicri:Area/Pmc/Curation">000568</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000568</idno><idno type="wicri:Area/Pmc/Checkpoint">000429</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000429</idno><idno type="wicri:Area/Ncbi/Merge">000770</idno><idno type="wicri:Area/Ncbi/Curation">000770</idno><idno type="wicri:Area/Ncbi/Checkpoint">000770</idno><idno type="wicri:Area/Main/Merge">000473</idno><idno type="wicri:Area/Main/Curation">000473</idno><idno type="wicri:Area/Main/Exploration">000473</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Relaxant Action of Diclofenac Sodium on Mouse Airway Smooth Muscle</title><author><name sortKey="Chen, Chunfa" sort="Chen, Chunfa" uniqKey="Chen C" first="Chunfa" last="Chen">Chunfa Chen</name><affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Institute for Medical Biology, Hubei Provincial Key Laboratory for Protection and Application of Special Plant Germplasm in Wuling Area of China, College of Life Sciences, South-Central University for Nationalities</institution>,<addr-line>Wuhan</addr-line>,<country>China</country></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Yang, Yongle" sort="Yang, Yongle" uniqKey="Yang Y" first="Yongle" last="Yang">Yongle Yang</name><affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Institute for Medical Biology, Hubei Provincial Key Laboratory for Protection and Application of Special Plant Germplasm in Wuling Area of China, College of Life Sciences, South-Central University for Nationalities</institution>,<addr-line>Wuhan</addr-line>,<country>China</country></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Yu, Meng Fei" sort="Yu, Meng Fei" uniqKey="Yu M" first="Meng-Fei" last="Yu">Meng-Fei Yu</name><affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Institute for Medical Biology, Hubei Provincial Key Laboratory for Protection and Application of Special Plant Germplasm in Wuling Area of China, College of Life Sciences, South-Central University for Nationalities</institution>,<addr-line>Wuhan</addr-line>,<country>China</country></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Shi, Shunbo" sort="Shi, Shunbo" uniqKey="Shi S" first="Shunbo" last="Shi">Shunbo Shi</name><affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Institute for Medical Biology, Hubei Provincial Key Laboratory for Protection and Application of Special Plant Germplasm in Wuling Area of China, College of Life Sciences, South-Central University for Nationalities</institution>,<addr-line>Wuhan</addr-line>,<country>China</country></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Han, Shuhui" sort="Han, Shuhui" uniqKey="Han S" first="Shuhui" last="Han">Shuhui Han</name><affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Institute for Medical Biology, Hubei Provincial Key Laboratory for Protection and Application of Special Plant Germplasm in Wuling Area of China, College of Life Sciences, South-Central University for Nationalities</institution>,<addr-line>Wuhan</addr-line>,<country>China</country></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Liu, Qing Hua" sort="Liu, Qing Hua" uniqKey="Liu Q" first="Qing-Hua" last="Liu">Qing-Hua Liu</name><affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Institute for Medical Biology, Hubei Provincial Key Laboratory for Protection and Application of Special Plant Germplasm in Wuling Area of China, College of Life Sciences, South-Central University for Nationalities</institution>,<addr-line>Wuhan</addr-line>,<country>China</country></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Cai, Congli" sort="Cai, Congli" uniqKey="Cai C" first="Congli" last="Cai">Congli Cai</name><affiliation wicri:level="1"><nlm:aff id="aff2"><institution>Department of Molecular Biology, Wuhan Youzhiyou Biopharmaceutical Co. Ltd.</institution>,<addr-line>Wuhan</addr-line>,<country>China</country></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Shen, Jinhua" sort="Shen, Jinhua" uniqKey="Shen J" first="Jinhua" last="Shen">Jinhua Shen</name><affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Institute for Medical Biology, Hubei Provincial Key Laboratory for Protection and Application of Special Plant Germplasm in Wuling Area of China, College of Life Sciences, South-Central University for Nationalities</institution>,<addr-line>Wuhan</addr-line>,<country>China</country></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author></analytic><series><title level="j">Frontiers in Pharmacology</title><idno type="eISSN">1663-9812</idno><imprint><date when="2019">2019</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Diclofenac sodium (DCF) is a nonsteroidal anti-inflammatory drug (NSAID) and is widely used as an analgesic and anti-inflammatory agent. Herein, we found that DCF could relax high K<sup>+</sup> (80 mM K<sup>+</sup>)-/ACh-precontracted tracheal rings (TRs) in mice. This study aimed to elucidate the underlying mechanisms of DCF-induced relaxations. The effects of DCF on airway smooth muscle (ASM) cells were explored using multiple biophysiological techniques, such as isometric tension measurement and patch-clamping experiments. Both high K<sup>+</sup>- and ACh-evoked contraction of TRs in mice were relaxed by DCF in a dose-dependent manner. The results of isometric tension and patch-clamping experiments demonstrated that DCF-induced relaxation in ASM cells was mediated by cytosolic free Ca<sup>2+</sup>, which was decreased via inhibition of voltage-dependent L-type Ca<sup>2+</sup> channels (VDLCCs), nonselective cation channels (NSCCs), and Na<sup>+/</sup>Ca<sup>2+</sup> exchange. Meanwhile, DCF also enhanced large conductance Ca<sup>2+</sup> activated K<sup>+</sup> (BK) channels, which led to the relaxation of ASMs. Our data demonstrated that DCF relaxed ASMs by decreasing the intracellular Ca<sup>2+</sup> concentration via inhibition of Ca<sup>2+</sup> influx and Na<sup>+</sup>/Ca<sup>2+</sup> exchange. Meanwhile, the enhanced BK channels also played a role in DCF-induced relaxation in ASMs. These results suggest that DCF is a potential candidate for antibronchospasmic drugs used in treating respiratory diseases such as asthma and chronic obstructive pulmonary disease.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Adams, N P" uniqKey="Adams N">N. P. Adams</name></author><author><name sortKey="Jones, P W" uniqKey="Jones P">P. W. Jones</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Arumugam, A" uniqKey="Arumugam A">A. Arumugam</name></author><author><name sortKey="Weng, Z" uniqKey="Weng Z">Z. Weng</name></author><author><name sortKey="Talwelkar, S S" uniqKey="Talwelkar S">S. S. Talwelkar</name></author><author><name sortKey="Chaudhary, S C" uniqKey="Chaudhary S">S. C. Chaudhary</name></author><author><name sortKey="Kopelovich, L" uniqKey="Kopelovich L">L. Kopelovich</name></author><author><name sortKey="Elmets, C A" uniqKey="Elmets C">C. A. Elmets</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Asher, M I" uniqKey="Asher M">M. I. Asher</name></author><author><name sortKey="Montefort, S" uniqKey="Montefort S">S. Montefort</name></author><author><name sortKey="Bjorksten, B" uniqKey="Bjorksten B">B. Bjorksten</name></author><author><name sortKey="Lai, C K" uniqKey="Lai C">C. K. Lai</name></author><author><name sortKey="Strachan, D P" uniqKey="Strachan D">D. P. Strachan</name></author><author><name sortKey="Weiland, S K" uniqKey="Weiland S">S. K. Weiland</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Black, J L" uniqKey="Black J">J. L. Black</name></author><author><name sortKey="Oliver, B G G" uniqKey="Oliver B">B. G. G. Oliver</name></author><author><name sortKey="Roth, M" uniqKey="Roth M">M. Roth</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bosetti, F" uniqKey="Bosetti F">F. Bosetti</name></author><author><name sortKey="Weerasinghe, G R" uniqKey="Weerasinghe G">G. R. Weerasinghe</name></author><author><name sortKey="Rosenberger, T A" uniqKey="Rosenberger T">T. A. Rosenberger</name></author><author><name sortKey="Rapoport, S I" uniqKey="Rapoport S">S. I. Rapoport</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Brooks, G" uniqKey="Brooks G">G. Brooks</name></author><author><name sortKey="Yu, X M" uniqKey="Yu X">X. M. Yu</name></author><author><name sortKey="Wang, Y" uniqKey="Wang Y">Y. Wang</name></author><author><name sortKey="Crabbe, M J" uniqKey="Crabbe M">M. J. Crabbe</name></author><author><name sortKey="Shattock, M J" uniqKey="Shattock M">M. J. Shattock</name></author><author><name sortKey="Harper, J V" uniqKey="Harper J">J. V. Harper</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Cazzola, M" uniqKey="Cazzola M">M. Cazzola</name></author><author><name sortKey="Page, C P" uniqKey="Page C">C. P. Page</name></author><author><name sortKey="Rogliani, P" uniqKey="Rogliani P">P. Rogliani</name></author><author><name sortKey="Matera, M G" uniqKey="Matera M">M. G. Matera</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Coburn, R F" uniqKey="Coburn R">R. F. Coburn</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Drazen, J M" uniqKey="Drazen J">J. M. Drazen</name></author><author><name sortKey="Fanta, C H" uniqKey="Fanta C">C. H. Fanta</name></author><author><name sortKey="Lacouture, P G" uniqKey="Lacouture P">P. G. Lacouture</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Fedan, J S" uniqKey="Fedan J">J. S. Fedan</name></author><author><name sortKey="Yuan, L X" uniqKey="Yuan L">L. X. Yuan</name></author><author><name sortKey="Chang, V C" uniqKey="Chang V">V. C. Chang</name></author><author><name sortKey="Viola, J O" uniqKey="Viola J">J. O. Viola</name></author><author><name sortKey="Cutler, D" uniqKey="Cutler D">D. Cutler</name></author><author><name sortKey="Pettit, L L" uniqKey="Pettit L">L. L. Pettit</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Fuller, P" uniqKey="Fuller P">P. Fuller</name></author><author><name sortKey="Roth, S" uniqKey="Roth S">S. Roth</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Gallos, G" uniqKey="Gallos G">G. Gallos</name></author><author><name sortKey="Townsend, E" uniqKey="Townsend E">E. Townsend</name></author><author><name sortKey="Yim, P" uniqKey="Yim P">P. Yim</name></author><author><name sortKey="Virag, L" uniqKey="Virag L">L. Virag</name></author><author><name sortKey="Zhang, Y" uniqKey="Zhang Y">Y. Zhang</name></author><author><name sortKey="Xu, D" uniqKey="Xu D">D. Xu</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Gao, Y" uniqKey="Gao Y">Y. Gao</name></author><author><name sortKey="Vanhoutte, P M" uniqKey="Vanhoutte P">P. M. Vanhoutte</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Halaszovich, C R" uniqKey="Halaszovich C">C. R. Halaszovich</name></author><author><name sortKey="Zitt, C" uniqKey="Zitt C">C. Zitt</name></author><author><name sortKey="Jungling, E" uniqKey="Jungling E">E. Jungling</name></author><author><name sortKey="Luckhoff, A" uniqKey="Luckhoff A">A. Luckhoff</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Haley, R M" uniqKey="Haley R">R. M. Haley</name></author><author><name sortKey="Von Recum, H A" uniqKey="Von Recum H">H. A. von Recum</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hawkey, C J" uniqKey="Hawkey C">C. J. Hawkey</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Huang, J" uniqKey="Huang J">J. Huang</name></author><author><name sortKey="Ma, L Q" uniqKey="Ma L">L. Q. Ma</name></author><author><name sortKey="Yang, Y" uniqKey="Yang Y">Y. Yang</name></author><author><name sortKey="Wen, N" uniqKey="Wen N">N. Wen</name></author><author><name sortKey="Zhou, W" uniqKey="Zhou W">W. Zhou</name></author><author><name sortKey="Cai, C" uniqKey="Cai C">C. Cai</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kitamura, S" uniqKey="Kitamura S">S. Kitamura</name></author><author><name sortKey="Ishihara, Y" uniqKey="Ishihara Y">Y. Ishihara</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kowalski, M L" uniqKey="Kowalski M">M. L. Kowalski</name></author><author><name sortKey="Wojciechowski, P" uniqKey="Wojciechowski P">P. Wojciechowski</name></author><author><name sortKey="Dziewonska, M" uniqKey="Dziewonska M">M. Dziewonska</name></author><author><name sortKey="Rys, P" uniqKey="Rys P">P. Rys</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ku, E C" uniqKey="Ku E">E. C. Ku</name></author><author><name sortKey="Kothari, H" uniqKey="Kothari H">H. Kothari</name></author><author><name sortKey="Lee, W" uniqKey="Lee W">W. Lee</name></author><author><name sortKey="Kimble, E F" uniqKey="Kimble E">E. F. Kimble</name></author><author><name sortKey="Liauw, L H" uniqKey="Liauw L">L. H. Liauw</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Li, M" uniqKey="Li M">M. Li</name></author><author><name sortKey="Shang, Y X" uniqKey="Shang Y">Y. X. Shang</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Liu, X C" uniqKey="Liu X">X. C. Liu</name></author><author><name sortKey="Wang, Q" uniqKey="Wang Q">Q. Wang</name></author><author><name sortKey="She, Y S" uniqKey="She Y">Y. S. She</name></author><author><name sortKey="Chen, S" uniqKey="Chen S">S. Chen</name></author><author><name sortKey="Luo, X" uniqKey="Luo X">X. Luo</name></author><author><name sortKey="Xu, H" uniqKey="Xu H">H. Xu</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Liu, B" uniqKey="Liu B">B. Liu</name></author><author><name sortKey="Liu, Y" uniqKey="Liu Y">Y. Liu</name></author><author><name sortKey="Shi, R" uniqKey="Shi R">R. Shi</name></author><author><name sortKey="Feng, X" uniqKey="Feng X">X. Feng</name></author><author><name sortKey="Li, X" uniqKey="Li X">X. Li</name></author><author><name sortKey="Zhang, W" uniqKey="Zhang W">W. Zhang</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lo, P C" uniqKey="Lo P">P. C. Lo</name></author><author><name sortKey="Tsai, Y T" uniqKey="Tsai Y">Y. T. Tsai</name></author><author><name sortKey="Lin, S K" uniqKey="Lin S">S. K. Lin</name></author><author><name sortKey="Lai, J N" uniqKey="Lai J">J. N. Lai</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lotvall, J" uniqKey="Lotvall J">J. Lotvall</name></author><author><name sortKey="Akdis, C A" uniqKey="Akdis C">C. A. Akdis</name></author><author><name sortKey="Bacharier, L B" uniqKey="Bacharier L">L. B. Bacharier</name></author><author><name sortKey="Bjermer, L" uniqKey="Bjermer L">L. Bjermer</name></author><author><name sortKey="Casale, T B" uniqKey="Casale T">T. B. Casale</name></author><author><name sortKey="Custovic, A" uniqKey="Custovic A">A. Custovic</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Mcnicol, E D" uniqKey="Mcnicol E">E. D. McNicol</name></author><author><name sortKey="Ferguson, M C" uniqKey="Ferguson M">M. C. Ferguson</name></author><author><name sortKey="Schumann, R" uniqKey="Schumann R">R. Schumann</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Morales, D R" uniqKey="Morales D">D. R. Morales</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="O Rady, M" uniqKey="O Rady M">M. O’Grady</name></author><author><name sortKey="Hackney, A C" uniqKey="Hackney A">A. C. Hackney</name></author><author><name sortKey="Schneider, K" uniqKey="Schneider K">K. Schneider</name></author><author><name sortKey="Bossen, E" uniqKey="Bossen E">E. Bossen</name></author><author><name sortKey="Steinberg, K" uniqKey="Steinberg K">K. Steinberg</name></author><author><name sortKey="Douglas, J M" uniqKey="Douglas J">J. M. Douglas</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Perez Vallina, J R" uniqKey="Perez Vallina J">J. R. Perez Vallina</name></author><author><name sortKey="Menendez Antolin, L" uniqKey="Menendez Antolin L">L. Menendez Antolin</name></author><author><name sortKey="Cantabrana, B" uniqKey="Cantabrana B">B. Cantabrana</name></author><author><name sortKey="Sanchez, M" uniqKey="Sanchez M">M. Sanchez</name></author><author><name sortKey="Hidalgo, A" uniqKey="Hidalgo A">A. Hidalgo</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Qian, L L" uniqKey="Qian L">L. L. Qian</name></author><author><name sortKey="Sun, M Q" uniqKey="Sun M">M. Q. Sun</name></author><author><name sortKey="Wang, R X" uniqKey="Wang R">R. X. Wang</name></author><author><name sortKey="Lu, T" uniqKey="Lu T">T. Lu</name></author><author><name sortKey="Wu, Y" uniqKey="Wu Y">Y. Wu</name></author><author><name sortKey="Dang, S P" uniqKey="Dang S">S. P. Dang</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Rahman, M" uniqKey="Rahman M">M. Rahman</name></author><author><name sortKey="Inman, M" uniqKey="Inman M">M. Inman</name></author><author><name sortKey="Kiss, L" uniqKey="Kiss L">L. Kiss</name></author><author><name sortKey="Janssen, L J" uniqKey="Janssen L">L. J. Janssen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Reyes Garcia, J" uniqKey="Reyes Garcia J">J. Reyes-Garcia</name></author><author><name sortKey="Flores Soto, E" uniqKey="Flores Soto E">E. Flores-Soto</name></author><author><name sortKey="Carbajal Garcia, A" uniqKey="Carbajal Garcia A">A. Carbajal-Garcia</name></author><author><name sortKey="Sommer, B" uniqKey="Sommer B">B. Sommer</name></author><author><name sortKey="Montano, L M" uniqKey="Montano L">L. M. Montano</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Sathish, V" uniqKey="Sathish V">V. Sathish</name></author><author><name sortKey="Delmotte, P F" uniqKey="Delmotte P">P. F. Delmotte</name></author><author><name sortKey="Thompson, M A" uniqKey="Thompson M">M. A. Thompson</name></author><author><name sortKey="Pabelick, C M" uniqKey="Pabelick C">C. M. Pabelick</name></author><author><name sortKey="Sieck, G C" uniqKey="Sieck G">G. C. Sieck</name></author><author><name sortKey="Prakash, Y S" uniqKey="Prakash Y">Y. S. Prakash</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Schmidt, M" uniqKey="Schmidt M">M. Schmidt</name></author><author><name sortKey="Sorensen, H T" uniqKey="Sorensen H">H. T. Sorensen</name></author><author><name sortKey="Pedersen, L" uniqKey="Pedersen L">L. Pedersen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Shalaby, K H" uniqKey="Shalaby K">K. H. Shalaby</name></author><author><name sortKey="Gold, L G" uniqKey="Gold L">L. G. Gold</name></author><author><name sortKey="Schuessler, T F" uniqKey="Schuessler T">T. F. Schuessler</name></author><author><name sortKey="Martin, J G" uniqKey="Martin J">J. G. Martin</name></author><author><name sortKey="Robichaud, A" uniqKey="Robichaud A">A. Robichaud</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Shigeki, K" uniqKey="Shigeki K">K. Shigeki</name></author><author><name sortKey="Kenta, K" uniqKey="Kenta K">K. Kenta</name></author><author><name sortKey="Motohiro, N" uniqKey="Motohiro N">N. Motohiro</name></author><author><name sortKey="Kazuhiro, M" uniqKey="Kazuhiro M">M. Kazuhiro</name></author><author><name sortKey="Takuro, N" uniqKey="Takuro N">N. Takuro</name></author><author><name sortKey="Yuichi, S" uniqKey="Yuichi S">S. Yuichi</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Sivrikaya, A" uniqKey="Sivrikaya A">A. Sivrikaya</name></author><author><name sortKey="Celik, O F" uniqKey="Celik O">O. F. Celik</name></author><author><name sortKey="Sivrikaya, N" uniqKey="Sivrikaya N">N. Sivrikaya</name></author><author><name sortKey="Ozgur, G K" uniqKey="Ozgur G">G. K. Ozgur</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Somlyo, A P" uniqKey="Somlyo A">A. P. Somlyo</name></author><author><name sortKey="Somlyo, A V" uniqKey="Somlyo A">A. V. Somlyo</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Sommer, B" uniqKey="Sommer B">B. Sommer</name></author><author><name sortKey="Flores Soto, E" uniqKey="Flores Soto E">E. Flores-Soto</name></author><author><name sortKey="Gonzalez Avila, G" uniqKey="Gonzalez Avila G">G. Gonzalez-Avila</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Stoloff, S W" uniqKey="Stoloff S">S. W. Stoloff</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Tan, J H Y" uniqKey="Tan J">J. H. Y. Tan</name></author><author><name sortKey="Hsu, A A L" uniqKey="Hsu A">A. A. L. Hsu</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Tan, H" uniqKey="Tan H">H. Tan</name></author><author><name sortKey="Lei, J" uniqKey="Lei J">J. Lei</name></author><author><name sortKey="Xue, L" uniqKey="Xue L">L. Xue</name></author><author><name sortKey="Cai, C" uniqKey="Cai C">C. Cai</name></author><author><name sortKey="Liu, Q H" uniqKey="Liu Q">Q. H. Liu</name></author><author><name sortKey="Shen, J" uniqKey="Shen J">J. Shen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wang, P" uniqKey="Wang P">P. Wang</name></author><author><name sortKey="Zhao, W" uniqKey="Zhao W">W. Zhao</name></author><author><name sortKey="Sun, J" uniqKey="Sun J">J. Sun</name></author><author><name sortKey="Tao, T" uniqKey="Tao T">T. Tao</name></author><author><name sortKey="Chen, X" uniqKey="Chen X">X. Chen</name></author><author><name sortKey="Zheng, Y Y" uniqKey="Zheng Y">Y. Y. Zheng</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wang, Q" uniqKey="Wang Q">Q. Wang</name></author><author><name sortKey="Yu, M F" uniqKey="Yu M">M. F. Yu</name></author><author><name sortKey="Zhang, W J" uniqKey="Zhang W">W. J. Zhang</name></author><author><name sortKey="Liu, B B" uniqKey="Liu B">B. B. Liu</name></author><author><name sortKey="Zhao, Q Y" uniqKey="Zhao Q">Q. Y. Zhao</name></author><author><name sortKey="Luo, X" uniqKey="Luo X">X. Luo</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Warner, T D" uniqKey="Warner T">T. D. Warner</name></author><author><name sortKey="Giuliano, F" uniqKey="Giuliano F">F. Giuliano</name></author><author><name sortKey="Vojnovic, I" uniqKey="Vojnovic I">I. Vojnovic</name></author><author><name sortKey="Bukasa, A" uniqKey="Bukasa A">A. Bukasa</name></author><author><name sortKey="Mitchell, J A" uniqKey="Mitchell J">J. A. Mitchell</name></author><author><name sortKey="Vane, J R" uniqKey="Vane J">J. R. Vane</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wei, M Y" uniqKey="Wei M">M. Y. Wei</name></author><author><name sortKey="Xue, L" uniqKey="Xue L">L. Xue</name></author><author><name sortKey="Tan, L" uniqKey="Tan L">L. Tan</name></author><author><name sortKey="Sai, W B" uniqKey="Sai W">W. B. Sai</name></author><author><name sortKey="Liu, X C" uniqKey="Liu X">X. C. Liu</name></author><author><name sortKey="Jiang, Q J" uniqKey="Jiang Q">Q. J. Jiang</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wen, J" uniqKey="Wen J">J. Wen</name></author><author><name sortKey="Meng, X" uniqKey="Meng X">X. Meng</name></author><author><name sortKey="Xuan, B" uniqKey="Xuan B">B. Xuan</name></author><author><name sortKey="Zhou, T" uniqKey="Zhou T">T. Zhou</name></author><author><name sortKey="Gao, H" uniqKey="Gao H">H. Gao</name></author><author><name sortKey="Dong, H" uniqKey="Dong H">H. Dong</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Yang, X" uniqKey="Yang X">X. Yang</name></author><author><name sortKey="Xue, L" uniqKey="Xue L">L. Xue</name></author><author><name sortKey="Zhao, Q" uniqKey="Zhao Q">Q. Zhao</name></author><author><name sortKey="Cai, C" uniqKey="Cai C">C. Cai</name></author><author><name sortKey="Liu, Q H" uniqKey="Liu Q">Q. H. Liu</name></author><author><name sortKey="Shen, J" uniqKey="Shen J">J. Shen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Yang, X" uniqKey="Yang X">X. Yang</name></author><author><name sortKey="Yu, M F" uniqKey="Yu M">M. F. Yu</name></author><author><name sortKey="Lei, J" uniqKey="Lei J">J. Lei</name></author><author><name sortKey="Peng, Y B" uniqKey="Peng Y">Y. B. Peng</name></author><author><name sortKey="Zhao, P" uniqKey="Zhao P">P. Zhao</name></author><author><name sortKey="Xue, L" uniqKey="Xue L">L. Xue</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Zhang, T" uniqKey="Zhang T">T. Zhang</name></author><author><name sortKey="Luo, X J" uniqKey="Luo X">X. J. Luo</name></author><author><name sortKey="Sai, W B" uniqKey="Sai W">W. B. Sai</name></author><author><name sortKey="Yu, M F" uniqKey="Yu M">M. F. Yu</name></author><author><name sortKey="Li, W E" uniqKey="Li W">W. E. Li</name></author><author><name sortKey="Ma, Y F" uniqKey="Ma Y">Y. F. Ma</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Zhang, X D" uniqKey="Zhang X">X. D. Zhang</name></author><author><name sortKey="He, C X" uniqKey="He C">C. X. He</name></author><author><name sortKey="Cheng, J" uniqKey="Cheng J">J. Cheng</name></author><author><name sortKey="Wen, J" uniqKey="Wen J">J. Wen</name></author><author><name sortKey="Li, P Y" uniqKey="Li P">P. Y. Li</name></author><author><name sortKey="Wang, N" uniqKey="Wang N">N. Wang</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Zhou, X B" uniqKey="Zhou X">X. B. Zhou</name></author><author><name sortKey="Wulfsen, I" uniqKey="Wulfsen I">I. Wulfsen</name></author><author><name sortKey="Lutz, S" uniqKey="Lutz S">S. Lutz</name></author><author><name sortKey="Utku, E" uniqKey="Utku E">E. Utku</name></author><author><name sortKey="Sausbier, U" uniqKey="Sausbier U">U. Sausbier</name></author><author><name sortKey="Ruth, P" uniqKey="Ruth P">P. Ruth</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>République populaire de Chine</li></country></list><tree><country name="République populaire de Chine"><noRegion><name sortKey="Chen, Chunfa" sort="Chen, Chunfa" uniqKey="Chen C" first="Chunfa" last="Chen">Chunfa Chen</name></noRegion><name sortKey="Cai, Congli" sort="Cai, Congli" uniqKey="Cai C" first="Congli" last="Cai">Congli Cai</name><name sortKey="Han, Shuhui" sort="Han, Shuhui" uniqKey="Han S" first="Shuhui" last="Han">Shuhui Han</name><name sortKey="Liu, Qing Hua" sort="Liu, Qing Hua" uniqKey="Liu Q" first="Qing-Hua" last="Liu">Qing-Hua Liu</name><name sortKey="Shen, Jinhua" sort="Shen, Jinhua" uniqKey="Shen J" first="Jinhua" last="Shen">Jinhua Shen</name><name sortKey="Shi, Shunbo" sort="Shi, Shunbo" uniqKey="Shi S" first="Shunbo" last="Shi">Shunbo Shi</name><name sortKey="Yang, Yongle" sort="Yang, Yongle" uniqKey="Yang Y" first="Yongle" last="Yang">Yongle Yang</name><name sortKey="Yu, Meng Fei" sort="Yu, Meng Fei" uniqKey="Yu M" first="Meng-Fei" last="Yu">Meng-Fei Yu</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Sante/explor/ChloroquineV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000473 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 000473 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Sante
|area= ChloroquineV1
|flux= Main
|étape= Exploration
|type= RBID
|clé= PMC:6591797
|texte= Relaxant Action of Diclofenac Sodium on Mouse Airway Smooth Muscle
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i -Sk "pubmed:31275141" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd \
| NlmPubMed2Wicri -a ChloroquineV1
| This area was generated with Dilib version V0.6.33. |  |